CAS 25655-41-8 refers to povidone-iodine, an iodine complex formed with povidone and widely used as a topical antiseptic and antimicrobial ingredient. For bulk purchasing, I recommend evaluating the product form, available iodine content, pharmacopoeial or regulatory requirements, packaging, documentation, and supply consistency rather than relying on the CAS number alone. Yuking can help B2B buyers review suitable grades, request current technical documents, and compare supply options according to the intended application.
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This guide is intended for pharmaceutical manufacturers, wound-care producers, veterinary-product companies, healthcare distributors, contract manufacturers, and industrial buyers sourcing CAS 25655-41-8 in commercial quantities. It is also useful for procurement teams that need to compare powder, solution, or application-specific grades before requesting a quotation. I focus on practical purchasing decisions rather than recommending a specific medical use or dosage.
Povidone-iodine products are regulated differently depending on the country, product category, concentration, and intended use. A raw-material buyer should therefore confirm the applicable local requirements with its regulatory and quality teams before placing a production order. In the United States, FDA drug labeling and DailyMed records provide product-specific information rather than one universal specification for every povidone-iodine material.
Povidone-iodine is a complex of iodine and povidone, also known as polyvinylpyrrolidone or PVP. The povidone acts as a carrier for iodine, while the available iodine is associated with the antimicrobial function of the finished formulation. The material is commonly recognized in topical antiseptic products, but its actual performance depends on formulation, concentration, contact time, organic load, packaging, and regulatory status.
One important purchasing distinction is the difference between total povidone-iodine concentration and available iodine concentration. For example, a commercial product labeled as 10% povidone-iodine may contain approximately 1% available iodine, but buyers must verify the exact value on the product specification and certificate of analysis. I do not recommend treating “10%” as a complete specification without confirming the assay method and reporting basis.
PubChem identifies povidone-iodine under CAS 25655-41-8 and provides chemical and safety information for reference. For a commercial order, I recommend using the supplier’s current specification, SDS, CoA, and regulatory documentation as the controlling documents for the purchased lot. Source: PubChem, Povidone-Iodine.
Solid material may be selected by manufacturers that formulate solutions, gels, ointments, sprays, or other dosage forms. Buyers normally review appearance, identification, iodine assay, available iodine, moisture or loss on drying, pH after preparation, particle characteristics, and microbiological requirements. The appropriate limits are grade-specific and should be confirmed before approval.
Liquid povidone-iodine is generally purchased when the buyer needs a ready-to-use or concentrated intermediate formulation. Important variables can include nominal concentration, available iodine, pH, viscosity, density, color, container compatibility, preservative system, and stability data. A solution that is suitable for one packaging system may not be suitable for another because iodine can interact with light, reducing materials, or incompatible container components.
Pharmaceutical, veterinary, cosmetic, and technical applications may require different documentation and controls. A buyer should not assume that a material sold for technical use can be used in a regulated medicinal product. I recommend confirming the intended market, dosage form, site of use, and applicable monograph before asking a supplier to quote.
| Application area | Typical purchasing focus | Key qualification question |
|---|---|---|
| Topical antiseptic formulations | Available iodine, assay, stability, packaging, and regulatory documents | Does the grade meet the finished-product and market requirements? |
| Wound-care products | Microbiological quality, compatibility, irritation-related formulation review, and batch consistency | Has the formulation been evaluated for the intended use? |
| Veterinary products | Target-market regulations, dosage form, labeling, and packaging | Is the documentation suitable for veterinary registration? |
| Laboratory or technical applications | Assay, packaging, SDS, and cost efficiency | Is pharmaceutical-grade documentation actually required? |
These categories describe procurement considerations, not automatic approvals or clinical recommendations. Product suitability must be demonstrated through the buyer’s formulation development, quality system, and regulatory review. The FDA’s Drug Facts labeling for specific povidone-iodine products illustrates why concentration, directions, warnings, and intended use must be assessed at the finished-product level rather than inferred from the CAS number alone.
I recommend requesting a complete specification instead of accepting only a product name and CAS number. At minimum, the document should identify the material, grade, appearance, identification test, assay or iodine content, available iodine, water or moisture parameter, pH where applicable, microbiological limits, packaging, retest or expiry information, and storage conditions. The specification should also state the test methods or recognized standard used for each critical parameter.
| Parameter | Why it matters | Example of a measurable unit |
|---|---|---|
| Available iodine | Helps define the iodine available for the intended formulation | % w/w |
| Total povidone-iodine assay | Confirms the declared material strength | % w/w |
| Moisture or loss on drying | Supports consistency, handling, and stability assessment | % w/w |
| pH | Important for formulation compatibility and product stability | pH units |
| Microbial quality | Supports the buyer’s quality-risk assessment | CFU/g or CFU/mL |
| Packaging quantity | Influences storage, handling, and freight planning | kg per drum or container |
Not every grade will use the same limits or test methods. For example, a powder and a liquid may require different approaches to pH, viscosity, density, and microbial testing. I advise buyers to approve the specification before commercial production and to compare the CoA against that approved version for every shipment.
Start with the final application, target market, dosage form, and required concentration. State whether you need a raw material for further formulation or a finished bulk solution. This information helps a supplier recommend a relevant grade and prevents a technically unsuitable quotation.
Ask whether the product needs to comply with a specific pharmacopoeia, internal standard, customer specification, or local regulation. Request the current CoA, SDS, technical data sheet, specification, and available manufacturing or quality-system documents. If a certificate or compliance statement is required, confirm its exact scope rather than accepting a general claim.
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Iodine-containing materials require careful consideration of light exposure, temperature, moisture, closure integrity, and compatibility with the container. The supplier should state recommended storage conditions, packaging material, net weight, pallet configuration, and retest or expiry policy where applicable. Buyers should also assess whether the material can remain within specification during the expected transport and storage period.
Before approving a large order, evaluate a representative sample using the buyer’s own analytical and formulation procedures. Check appearance, assay, available iodine, pH where relevant, processing behavior, and compatibility with the proposed packaging. A successful sample review does not replace formal batch-release controls, but it can reduce the risk of ordering a grade that does not fit the process.
The price of CAS 25655-41-8 can vary according to grade, available iodine specification, production scale, packaging, testing, documentation, destination, and order quantity. I do not recommend using an unverified online price as a procurement benchmark because a low quoted price may exclude testing, special packaging, freight, or regulatory documents. A comparable request for quotation should specify quantity in kilograms, delivery term, destination port, packaging format, required documents, and target delivery window.
MOQ and lead time are supplier- and grade-dependent. A standard industrial pack may have a different MOQ from a customized pharmaceutical batch, and a first order may require additional qualification time. As a practical starting point, buyers can request quotations for 25 kg, 100 kg, and 1,000 kg scenarios, but these are planning examples rather than guaranteed package sizes or minimum orders.
For each commercial lot, I suggest requesting a batch-specific CoA, SDS, packing list, commercial invoice, and applicable origin or export documents. Depending on the project, buyers may also need a manufacturing statement, allergen or animal-origin statement, residual-solvent information, elemental-impurity information, change-control commitment, or stability-related data. Documentation availability must be confirmed before purchase because not every supplier maintains the same document package.
The United States Pharmacopeia explains that monographs and general chapters provide compendial quality standards for materials and products, but buyers must verify whether a particular material and market require a USP or another pharmacopoeial standard. Source: United States Pharmacopeia, standards and monographs information.
For B2B procurement, I consider communication quality and document accuracy almost as important as the initial price. A supplier that answers specification questions clearly can help reduce formulation, customs, and batch-release delays. However, buyers should still complete their own vendor qualification and should not treat a supplier discussion as a substitute for regulatory approval.
The most common mistake is purchasing by CAS number alone. CAS 25655-41-8 identifies the substance, but it does not define the buyer’s required concentration, grade, packaging, test method, or regulatory status. Another frequent error is confusing a nominal 10% povidone-iodine label with 10% available iodine, which can lead to incorrect formulation calculations.
Buyers also sometimes request a quotation without specifying the destination, quantity, packaging, document requirements, or delivery schedule. This makes supplier offers difficult to compare and may produce unexpected charges later. I recommend issuing a short technical purchasing brief before requesting prices.
Yuking can review your intended application and help organize an inquiry for CAS 25655-41-8, including the required product form, target quantity, specification parameters, packaging, and documentation. We can also help compare standard versus application-specific requirements, subject to confirmation from the relevant production and quality teams. Any quoted specification, MOQ, lead time, and document availability should be confirmed for the individual order.
To receive a more useful quotation, please provide the required grade, estimated annual or trial quantity, destination country, preferred packaging, intended application, applicable standard, and required documents. If your project is still at the evaluation stage, a sample-and-document request can be a practical first step. We can then review the technical requirements before discussing commercial terms.
For a reliable bulk purchase of CAS 25655-41-8, I recommend treating the material as a specification-controlled ingredient rather than a commodity identified only by its CAS number. First define the final application and market, then approve the required grade, available iodine range, test methods, packaging, documents, and delivery conditions. After that, evaluate a sample or pilot lot and compare the supplier’s batch CoA with the approved specification.
If you are sourcing povidone-iodine for pharmaceutical, veterinary, wound-care, laboratory, or other B2B applications, send Yuking your target quantity, destination, product form, quality standard, and documentation requirements. We can use those details to prepare a more relevant supply review and quotation request without making unsupported assumptions about your project.
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